QUADRI MENINGOTM :
(Meningococcal Polysaccharide Vaccine)
(Group A, C, Y & W135)

Meningitis or Meningococcemia is caused by Neisseria meningitidis (Groups A, C, Y, W135) bacteria. It may be severe and life threatening. A variety of neurological and immunological complications are generally associated with the primary disease.

DESCRIPTION :
QUADRI MENINGOTM is to be used to protect against cerebrospinal meningitis and other diseases caused by Neisseria meningitidis (Group A, C, Y & W 135). Quadri MeningoTM meets the quality standards set by W.H.O. T.R.S. 594 (1976), 658 (1981) , 904 ( 2002) and conforms to the I.P.

COMPOSITION :
Each dose (0.5 ml) of vaccine contains :
Particulars Quantity
Purified Polysaccahride of Neisseria meningitidis Group A 50 mcg
Purified Polysaccahride of Neisseria meningitidis Group C 50 mcg
Purified Polysaccahride of Neisseria meningitidis Group Y 50 mcg
Purified Polysaccahride of Neisseria meningitidis Group W 135 50 mcg
Lactose I.P. (Stablizer) 5 mg
Thimerosal I.P. (Preservative) 0.05 mg

INDICATIONS :

  • Hajj and Umrah pilgrims heading to Mecca, Saudi Arabia.
  • Children and person exposed to infected patients.
  • Recommended for children above 18 months of age as routine immunization in endemic areas.
  • Travellers heading to disease prone areas should be vaccinated at least 15 days in advance.
  • Military recruits.
  • During epidemic, children between 3-18 months need to be vaccinated 3 months apart. Revaccination is recommended in children at high risk areas who were vaccinated below 4 years of age.

PRESENTATION :
QUADRI MENINGOTM is available in single dose vial with syringe and 10 dose vial packing along with diluent ( Isotonic Saline ).

DOSAGE AND ADMINISTRATION :
Reconstitute QUADRI MENINGOTM with diluent (0.5 ml for one dose, 5 ml for 10 doses) yielding clear solution. Inject 0.5 ml as S/C or I/M injection.

CONTRA- INDICATION :
• Hypersensitivity to any of the vaccine component.
• Ongoing acute or chronic illness like fever, severe infection, persistant diarrhoea, vomitting.

SIDE EFFECTS :
As in the case of other polysaccharide antigen based vaccines, slight erythema and induration is seen during first 24-48 hrs of injection, which disappears after 72 hrs. In 1-2% cases mild fever (990-1010F) has been observed lasting for 24-48 hrs only. Usually anti-allergic and antipyretic medication is given 1/2 hrs before vaccination to releive potential mild reactogenicity. 

STORAGE :
Store at 20-80C in refrigerator. Do not freeze. Product is good to use for 24 months from the date of manufacture.

OTHER INFORMATION :
W.H.O has recommended use of Quadrivalent Vaccine (containing A, C, Y & W 135 type antigens) in place of bivalent vaccine (containing only A, C type antigens) specially in areas like India where group specific meningococci, causing disease have not been identified.