Bio-Med

CLINICAL PICTURE OF TYPHOID FEVER

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[vc_row css=”.vc_custom_1512548178881{margin-bottom: 0px !important;}”][vc_column width=”1/4″][vc_single_image image=”3497″ img_size=”full”][/vc_column][vc_column width=”3/4″][vc_column_text]Typhoid fever exhibits in various forms. Typically, it starts with malaise, anorexia, muscular  aches and fevers,that increases everyday by 0.25-0.50C to reach to 39 to 410 C coupled with abdominal pain & headaches. Fever rises to 410 C in 5-7 days where it stays for 10-15 days if untreated, then fever decreases slowly over several days.

During the period of rise in fever, some patients (20%) with fair skin show “rose spots” of 2-4 mm in the chest, abdomen & back areas. Constipation is typically observed.

In blood – leukocytes are below 4500/mm3 & platelets less 80,000/mm3 . Liver dysfunction may be present and can be detected by elevated serum transaminase values.

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Two of most important complications are perforations & hemorrhage as a result of intestinal lesions (See figure).

Other uncommon complications are hepatitis, empyema, osteomyelitis & psychosis. Particularly severe form of typhoid can cause cerebral dysfunction, delirium or coma and shock, case fatality in such cases can exceed 20%.

About 2% to 5% patients become chronic gallbladder carriers of the organism where it has been implicated as a cause of cancer.

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CONTENTS
  1. Typhiod Fever -Introduction
  2. Epidemiology
  3. Clinical picture of typhoid fever
  4. Recent advances in understanding of Typhoid fever in infants
    1. Reports on a typical clinical picture of Typhoid in infants.
    2. Reports of typhoid fever in infants & children.
  5. Typhoid vaccines
    1.  Vi Polysaccharide typhoid vaccine
    2.  Vi Conjugate typhoid vaccine (Peda Typh™)
  6. Clinical trials
    1. Introduction
    2. Methods and materials
    3. Selection of volunteers
    4. Evaluation of safety
    5. Immunological response
  7. Prescribing information of Peda Typh™
  8. References

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